CD19-targeted pathway
Diffuse Large B-Cell Lymphoma (DLBCL)
For relapsed or refractory DLBCL after two or more lines of systemic therapy.
What the pathway typically involves:
- Pre-treatment PET-CT, bone marrow biopsy and cardiac function assessment
- T-cell collection (leukapheresis, 3–5 hours)
- Bridging chemotherapy if disease progression risk is high
- Lymphodepletion conditioning (3 days)
- CAR-T cell infusion (single session, 30–60 minutes)
- Inpatient monitoring for CRS and neurotoxicity (7–14 days)
- Response assessment at 1 and 3 months post-infusion
CD19-targeted CAR-T for DLBCL has published complete response rates of 50–70% in relapsed/refractory populations. Data sourced from peer-reviewed literature including the New England Journal of Medicine and Blood.




